Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human
The secondary lymphoid organs, which include the lymph nodes, the spleen, and mucosal associated lymphoid tissues, are the major sites of lymphocyte activation during adaptive immune responses ().In the absence of antigenic stimulation, resting B lymphocytes aggregate around a network of follicular dendritic cells (FDC), …
Reactive Versus Neoplastic Bone Marrow: Problems and …
Benign lymphoid aggregates may occur in the bone marrow in a variety of reactive conditions and are also more likely to be found in older individuals.30,38 Conditions associated with the presence of benign lymphoid aggregates include autoimmune diseases and HIV infection, as well as myeloid neoplasms, such as MDS and …
Tertiary Lymphoid Structures: Diversity in Their …
In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary lymphoid structures (TLSs). Mature TLSs are functional sites for the development of adaptive responses and, consequently, when present, can have an impact in both …
Ectopic lymphoid-like structures in infection, cancer and …
Ectopic lymphoid-like structure neogenesis is a common clinical occurrence and contributes to the pathology that is associated with cancer, autoimmunity, infection and tissue rejection.
The lymphoid system: a review of species differences
The human thymus begins the process of involution in the first 10 years of life and largely consists of fat and connective tissue by the time a human reaches the age of 30. ... Histologic changes in rectal lymphoid aggregates of dogs must be interpreted with caution as self–induced trauma and/or pathology of the adjacent anal glands can ...
Differentiating Benign From Malignant Bone Marrow B-Cell Lymphoid …
The presence of lymphoid aggregates in the bone marrow has been reported to be more frequently associated with certain conditions including aging, autoimmune diseases, inflammatory conditions, and infectious disorders. 2,9 They have also been reported to be commonly identified in patients with myeloproliferative …
Tertiary lymphoid structures in cancer | Science
Ectopic lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are formed in numerous cancer types, and, with few exceptions, their presence is associated with …
processing of human lymphoid aggregates
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Terminology: nomenclature of mucosa-associated lymphoid …
Human PPs occur mainly in the distal ileum and contain by definition between 5 and 200 aggregated lymphoid follicles. 30 Human PP anlagen, composed of CD4 + DCs, can be seen at 11 weeks of ...
CD8+ T cells in human uterine endometrial lymphoid aggregates: Evidence
Lymphoid aggregates (LA) develop during the proliferative phase of the menstrual cycle in the human uterine endometrium (EM). They contain mostly CD8+ T cells and B cells.
Human Lymphoid Histocultures
Here we describe a protocol to process and infect with human immunodeficiency virus (HIV) type 1 lymphoid tissue explants from human tonsils and maintain them in culture at the liquid-air interface in a non-polarized setting. ... In particular, the culture of human lymphoid tissue allowed HIV-1 infection and transmission to be studied under ...
Tertiary Lymphoid Structures: Diversity in Their Development
In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary …
Tertiary Lymphoid Structures: Autoimmunity Goes Local
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms …
Issues for patchy tissues: defining roles for gut-associated lymphoid …
A major constituent of GALT in humans comprises secretory lymphoid aggregates known as Peyer's patches that sense and combat constant exposure to pathogens and infectious agents. ... Both these regions contain highly organised lymphoid tissue that absorb and process antigens from the luminal content to initiate an …
Immune Profiling of Human Gut-Associated Lymphoid …
The intestine contains some of the most diverse and complex immune compartments in the body. Here we describe a method for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoid follicles (SM-ILFs and M-ILFs, …
Cancers | Free Full-Text | The Emerging Role of Tertiary Lymphoid …
This narrative review aims to clarify the role of tertiary lymphoid structures in breast cancer. We examine their development, composition, and prognostic value, and current ways of recognizing them. A comprehensive literature review was performed using the PubMed/Medline, Scopus, and EMBASE databases. A significant area of interest in …
Mechanisms of tertiary lymphoid structure formation: …
Defining tertiary lymphoid structures. TLS are B and T cell lymphoid aggregates observed histologically in chronically inflamed peripheral tissues such as those found in solid tumors, persistent infections, transplanted organs, and many autoimmune pathologies ().Reports on the tissue location of TLS varies and has caused some …
Group 3 innate lymphoid cells in intestinal health and disease
Shikhagaie, M. M. et al. Neuropilin-1 is expressed on lymphoid tissue residing LTi-like group 3 innate lymphoid cells and associated with ectopic lymphoid aggregates. Cell Rep. 18, 1761–1773 ...
Pathology of the Lymphoid System | SpringerLink
2.3 Bone Marrow. The bone marrow is the source of such cellular elements in the blood as red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes) (Travlos 2006b).Compared to other lymphoid organs, bone marrow exhibits little compartmentalization (Figs. 1 and 2) (Travlos 2006b).Relative to its function as a …
Development and physiological functions of the lymphatic …
Primary lymphoid organs, bone marrow and thymus, are the sites for immune cell production, whereas secondary lymphoid organs are sites where lymphocytes are activated (FIGURE 1A) . The term tertiary lymphoid organs (TLOs) has been introduced to describe inducible ectopic lymphoid aggregates in tissues as a result of chronic …
processing of human lymphoid aggregates
processing of human lymphoid aggregates . Lymphoid Aggregates in Endobronchial Biopsies from . Processing of Bronchial Biopsies. Bronchial biopsy specimens ... this is the first reported observation of ... WhatsApp. Review: Organs of the Immune System . Review: Organs of the Immune System ... Processing by APCs ... lymphoid aggregates.
Tertiary lymphoid structures (TLS) identification and density …
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their …
Lymphoid aggregates in the bone marrow biopsies of …
Clusters of lymphoid aggregates (LA) are occasionally observed in BMB of patients with non-lymphoproliferative disorders. We have noticed that, in addition to the known dysplastic features, LA are commonly reported as present in BMB of patients diagnosed with myelodysplastic syndromes (MDS). ... The studies involving human …
Tertiary lymphoid structures (TLS) identification and density …
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology …
Bioengineering translational models of lymphoid tissues
Recreating human immune biology poses a grand challenge owing to its unique complexity and diversity. This Review discusses advances in bioengineering lymphoid and mucosal tissues, with an ...
Mechanisms of tertiary lymphoid structure formation: …
The organization of tertiary lymphoid structures (TLS) in solid tumors is a unique example of a hot tumor whereby T and B lymphocytes aggregate with antigen …
New definitions of human lymphoid and follicular cell …
Unique 4D Dataset of lymphocytes inside fresh human lymphoid tissue sections. (E) represents the raw data (totaling 24 video sequences where only the first frame is shown).Each sample (i.e. a ...
Identification, isolation and analysis of human gut-associated lymphoid …
Fenton, T. M. et al. Immune profiling of human gut-associated lymphoid tissue identifies a role for isolated lymphoid follicles in priming of region-specific immunity. Immunity 52, 557–570.e6 (2020).
The roles of tertiary lymphoid structures in chronic diseases
Key points. Tertiary lymphoid structures (TLSs) are organized lymphoid aggregates that develop in perivascular areas in response to disturbed tissue …
B cells and tertiary lymphoid structures as determinants of …
B cells are a major component of the tumour microenvironment, where they are predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within mature TLS, B cell clones ...