Review of Disintegrants and the Disintegration Phenomena
This review aims to provide an overview of tablet disintegrants and the disintegration processes with particular focus on the factors affecting the functionalities of …
Vibration-assisted compaction of biomass :: BioResources
Also, the products readily expand and disintegrate because of the retention of internal stresses. In this study, tests on vibration-assisted compaction of biomass were performed as a method to reduce the energy requirement and to improve product quality. ... The vibration used to supplement the compaction process was introduced using an air ...
Experimental and numerical analysis of the effect of compaction
In order to determine the effect of compressive stress σ c, process temperature T, sawdust moisture content M, on briquette density D, its compressive strength CS, values of Young's modulus for sawdust E1 and briquette E2, its relaxation R, the energy consumption of the process EC and the work W needed for the compaction …
Using a Material Library to Understand the Impacts of Raw …
1. Introduction. Roll compaction (RC) is a dry agglomeration process, which can be run continuously and has high throughput [1,2,3,4,5,6].Compared to direct compression (DC), RC is more forgiving of input materials' bulk density and flowability, and can handle high drug-load formulations [].Compared to wet granulation (WG), RC offers …
AASHTO ASTM Asphalt Mixture Assessment Preparation …
Have materials ready to demonstrate mixing, compaction of the specimen, and testing the specimen. If the laboratory does not mix samples in-house, the mix should be heated to
Comparison of Superdisintegrants in Orally Disintegrating …
In fact, at a low use level (0.5–2%), Ac-Di-Sol was the only disintegrant among the three types that could effectively disintegrate tablets at all compaction force ranges. Even when the use level increased to 2%, Ac-Di-Sol was still the only disintegrant that could provide ODTs that meet the USP-required 30 s disintegration time at all ...
Tableting process-induced solid-state polymorphic transition
Background Polymorphism is that a substance exists into more than two crystalline forms with different molecular arrangements and/or conformations. It has been reported that the polymorphic transition significantly influences several important qualities of a solid drug product such as physical properties of dosage form, physicochemical …
The Basics of Embankment Construction
Compaction Control. Compaction control is an important element of embankment construction. The following factors are essential to the process: Typically, a test strip or Geotech lab results will determine the target density of …
Effect of compaction on particle size
It is shown that compacts made from different materials but of the same initial particle-size spectra disintegrate to give particles of a considerably different size. Determination of the change in particle size produced by the compaction process provides useful insight into the nature of the compaction process.
Itraconazole Amorphous Solid Dispersion Tablets: …
Round tablets were found to disintegrate under 20 min, whereas oblong tablets disintegrated within 10 min. The round tablets achieved over 80% ITZ release within 15 min, with six out of seven formulations achieving ITZ release by 30 min. ... In order to identify the CQAs, it is important to understand the compaction process using a V …
Procedure Adopted for Field Compaction Control | Soil Engineering
ADVERTISEMENTS: In this article we will discuss about:- 1. Parameters for Compaction Specification in the Field 2. Objective of Field Compaction Control 3. Determination of In-Situ Density. Parameters for Compaction Specification in the Field: The parameters used to ensure effective compaction in the field include (a) relative compaction and (b) …
(PDF) STUDY OF SAMPLES STRENGTH OF MATERIAL …
and disintegrate in the compaction process. [15] Figure 12. The results of the forces needed to break. and disintegrate in the extrusion process. tle effect. As can be clearly seen from the recorded.
Optimization of compaction pressure on brick
The Molding process of brick with size samples test of 5x5x5cm with variation compaction pressure: 0.5; 0.7; 0.9; 1.1; 1.3; and 1.5 MPa. Further drying is done without direct sunlight. The combustion process carried out test samples with methods that have been developed in previous studies, with rice husk fuel. The process of
Advancing the understanding of the tablet
Dry granulation/roller compaction is a method of tablets manufacturing that is gaining increasing popularity. However, little is known about the influence of the process parameters on the disintegration of tablets produced by this method (Quodbach and Kleinebudde, 2015). Rajikumar et al. have investigated the influence of roller …
compaction procedure to disintegrate
compaction procedure to disintegrate; Compaction Equipment Pavement Interactive. In general, steel wheel rollers provide the smoothest mat finish of all compaction equipment. When operated in the vibratory mode, they also provide substantial compactive effort. Pneumatic Tire Rollers. The pneumatic tire roller is a selfpropelled compaction ...
An overview of the different excipients useful for the direct
The existing popularity of wet granulation can be understood when considering the compaction process. As a powder is compressed within a die, the various stages of the compaction process can be separated as follows 1: ... Free flowing powders that disintegrate by dissolution, such as lactose, mannitol and maltose ...
Investigating Compaction by Intergranular Pressure Solution …
Intergranular pressure solution (IPS, sometimes referred to as (dis)solution-precipitation creep or even "chemical compaction") is known to be an important time …
Compaction Procedures, Specifications, and Control …
test for specifying compaction are discussed to show the uncertainty in the resulting maximum dry density and optimum moisture content. Factors that influence field …
Soil Compaction Handbook
There are five principle reasons to compact soil: Increases load-bearing capacity. Prevents soil settlement and frost damage. Provides stability. Reduces water seepage, swelling …
Field Compaction of Soil: 4 Procedures | Soil Engineering
Procedure # 3. Compaction of Soil in the Field: Compaction equipment can efficiently compact the soil up to a limited depth. Hence, the fills or embankments are compacted in several layers, called lifts. If lift thickness is too large, soil at the top of the lift will be well compacted whereas that at the bottom will not be compacted completely.
Compaction of food powders: The influence of material …
These blends were subsequently compacted on a compaction simulator under multiple process conditions through a design of experiments (DoE) approach. A T-shaped partial least squares (T-PLS) model was established which correlates tablet quality attributes with process settings, raw material properties and blend ratios. ...
A comprehensive understanding of disintegrants and …
Qualified tablet disintegration is the basis for ensuring effective drug release and curative effect. Delayed disintegration is defined as the inability of the tablet to …
Compaction of Soil: Definition, Principle and Effect | Soil Engineering
ADVERTISEMENTS: In this article we will discuss about:- 1. Introduction to the Compaction of Soils 2. Definition of Compaction 3. Principle 4. Effect 5. Factors 6. Method. Introduction to the Compaction of Soils: Soil is used as a construction material for constructing embankments and subgrades. Embankments are constructed to raise the …
Influence of amorphous content on compaction behaviour …
In the application as a filler-binder in compaction process the compaction behaviour of the used lactose quality is of utmost importance for the production of hard tablets with good disintegration properties and, therefore, good liberation of the active ingredient. ... The 2.0% amorphous modified tablets disintegrate within 10 ...
Manufacture of Tablets by Direct Compression Method
The processing of drug with excipients can be achieved without any need of granulation and related unit operations. By simply mixing in a blender, formulation ingredients can be processed and compressed into tablets without any of the ingredients having to be changed. This procedure is called direct compression and it is used in the …
The Impact of Disintegrant Type, Surfactant, and API
As described previously, the same process parameters were used for roller compaction of all batches. The key process parameters during compression as well as ribbon, granule, and tablet properties for acetaminophen batches and aspirin batches are summarized in Table I.The listed values are average of three measurements for envelop …
Tablet Disintegratability: Sensitivity of Superdisintegrants to
The compaction pressure also has a significant impact on tablet disintegration. Generally, the greater the compaction pressure, the longer the disintegration time will be [15,16,17]. This is because higher compaction pressures form stronger bonds between particles, and these bonds will take a longer time to be …
(PDF) Determination of compacting pressure and pressing …
The compaction process was carried out using the SIRIO P400 hydraulic press with a closed chamber with a diameter of 12 mm. Samples were made in four pressures: 131; 196; 262; 327 MPa and three ...
Soil Compaction: Methods, Meaning, and Effects
In this case, additional passes would be required to complete the compaction process. Slower equipment traveling speeds are often deemed necessary, especially when using vibratory equipment. Slower speeds of vibratory equipment allow more time for additional vibrations at a given point resulting in better compaction. …
Itraconazole Amorphous Solid Dispersion Tablets: …
Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools Pharmaceutics. 2022 Nov 7;14(11):2398. doi: 10.3390/pharmaceutics14112398. ... Round tablets were found to disintegrate under 20 min, whereas oblong tablets disintegrated …